Frontline Plus Flea & Tick Topical Treatment for Dogs

Frontline Plus for Dogs | Kills Fleas, Eggs, Larvae & Ticks, No Prescription Needed

Quick Facts:

• Best for: Dogs and puppies 8 weeks and older, 5+ lbs
• Main active ingredients: Fipronil & (S)-methoprene
• Format: Topical monthly applicator, 3- or 6-dose packs
• Key support: Kills fleas, flea eggs, flea larvae, chewing lice & ticks
• Prescription status: Not required — available over-the-counter
• Ideal for: Waterproof, month-long protection with minimal reapplication

Description: Frontline Plus has built two decades of brand trust around a two-ingredient approach: fipronil kills adult fleas, ticks, and chewing lice on contact, while (S)-methoprene works as an insect growth regulator, targeting flea eggs and larvae before they can mature into a new generation. This combination is specifically designed to break the flea life cycle rather than just killing what's currently visible on a dog's coat, which matters because adult fleas typically represent only a small fraction of an actual infestation at any given time. Applied to a single point on the dog's skin, the treatment spreads via the body's natural oils and collects in the sebaceous glands, which act as a reservoir that continues replenishing the product onto the coat and skin — a mechanism that keeps it working even after the dog gets wet or bathes. One dose provides a full 30 days of protection, and it's approved for puppies as young as 8 weeks old weighing 5 lbs or more. Frontline Plus is sold without a prescription and comes in weight-specific packaging (small, medium, large, and extra-large dog formulas) to ensure accurate dosing, and ticks killed include species capable of transmitting Lyme disease.